Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants

Tumor suppressor p53, a critical regulator of cell fate, is frequently mutated in cancer. Mutation of p53 abolishes its tumor-suppressing functions or endows oncogenic functions. We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is d...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Li, Yun, Bhattacharya, Arup, Zhang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655031/
https://www.ncbi.nlm.nih.gov/pubmed/34880421
http://dx.doi.org/10.1038/s42003-021-02880-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655031/
https://www.ncbi.nlm.nih.gov/pubmed/34880421
http://dx.doi.org/10.1038/s42003-021-02880-x

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