Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transit...

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Detalles Bibliográficos
Autores principales: Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655073/
https://www.ncbi.nlm.nih.gov/pubmed/34880245
http://dx.doi.org/10.1038/s41467-021-27460-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655073/
https://www.ncbi.nlm.nih.gov/pubmed/34880245
http://dx.doi.org/10.1038/s41467-021-27460-9

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