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Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury

INTRODUCTION: Intracellular calcium overload is an important contributor to myocardial ischemia/reperfusion (MI/R) injury. Total saponins of the traditional Chinese medicinal plant Aralia elata (Miq.) Seem. (AS) are beneficial for treating MI/R injury, and Calenduloside E (CE) is the main active ing...

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Detalles Bibliográficos
Autores principales: Wang, Ruiying, Wang, Min, Zhou, Jiahui, Dai, Ziru, Sun, Guibo, Sun, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655133/
https://www.ncbi.nlm.nih.gov/pubmed/35024189
http://dx.doi.org/10.1016/j.jare.2020.10.005