Epigenetic Heterogeneity in Friedreich Ataxia Underlies Variable FXN Reactivation

Friedreich ataxia (FRDA) is typically caused by homozygosity for an expanded GAA triplet-repeat in intron 1 of the FXN gene. The expanded repeat induces repressive histone changes and DNA hypermethylation, which result in epigenetic silencing and FXN transcriptional deficiency. A class I histone dea...

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Detalles Bibliográficos
Autores principales: Rodden, Layne N., Gilliam, Kaitlyn M., Lam, Christina, Lynch, David R., Bidichandani, Sanjay I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655727/
https://www.ncbi.nlm.nih.gov/pubmed/34899161
http://dx.doi.org/10.3389/fnins.2021.752921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655727/
https://www.ncbi.nlm.nih.gov/pubmed/34899161
http://dx.doi.org/10.3389/fnins.2021.752921

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