Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages

Background and purpose: FXR is a promising target for the treatment of human cholestatic liver disease (CLD). SIRT1 is a deacetylase which promotes FXR activity through deacetylating FXR. Pterostilbene (PTE) is an activator of SIRT1. However, the role of PTE in cholestasis has so far not been invest...

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Detalles Bibliográficos
Autores principales: Ma, Chuanrui, Xiang, Jiaqing, Huang, Guixiao, Zhao, Yaxi, Wang, Xinyu, Wu, Han, Jiang, Kewei, Liang, Zhen, Kang, Lin, Yang, Guangyan, Yang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656168/
https://www.ncbi.nlm.nih.gov/pubmed/34899349
http://dx.doi.org/10.3389/fphar.2021.785403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656168/
https://www.ncbi.nlm.nih.gov/pubmed/34899349
http://dx.doi.org/10.3389/fphar.2021.785403

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