Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern

The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Comput...

Descripción completa

Detalles Bibliográficos
Autores principales: Martín-Galiano, Antonio J., Díez-Fuertes, Francisco, McConnell, Michael J., López, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656262/
https://www.ncbi.nlm.nih.gov/pubmed/34899692
http://dx.doi.org/10.3389/fimmu.2021.732693
_version_ 1784612249169559552
author Martín-Galiano, Antonio J.
Díez-Fuertes, Francisco
McConnell, Michael J.
López, Daniel
author_facet Martín-Galiano, Antonio J.
Díez-Fuertes, Francisco
McConnell, Michael J.
López, Daniel
author_sort Martín-Galiano, Antonio J.
collection PubMed
description The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.
format Online
Article
Text
id pubmed-8656262
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86562622021-12-10 Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern Martín-Galiano, Antonio J. Díez-Fuertes, Francisco McConnell, Michael J. López, Daniel Front Immunol Immunology The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants. Frontiers Media S.A. 2021-11-25 /pmc/articles/PMC8656262/ /pubmed/34899692 http://dx.doi.org/10.3389/fimmu.2021.732693 Text en Copyright © 2021 Martín-Galiano, Díez-Fuertes, McConnell and López https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Martín-Galiano, Antonio J.
Díez-Fuertes, Francisco
McConnell, Michael J.
López, Daniel
Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_full Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_fullStr Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_full_unstemmed Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_short Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_sort predicted epitope abundance supports vaccine-induced cytotoxic protection against sars-cov-2 variants of concern
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656262/
https://www.ncbi.nlm.nih.gov/pubmed/34899692
http://dx.doi.org/10.3389/fimmu.2021.732693
work_keys_str_mv AT martingalianoantonioj predictedepitopeabundancesupportsvaccineinducedcytotoxicprotectionagainstsarscov2variantsofconcern
AT diezfuertesfrancisco predictedepitopeabundancesupportsvaccineinducedcytotoxicprotectionagainstsarscov2variantsofconcern
AT mcconnellmichaelj predictedepitopeabundancesupportsvaccineinducedcytotoxicprotectionagainstsarscov2variantsofconcern
AT lopezdaniel predictedepitopeabundancesupportsvaccineinducedcytotoxicprotectionagainstsarscov2variantsofconcern

Ejemplares similares