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Topoisomerase-Mediated DNA Damage in Neurological Disorders

The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant to the development of neuronal dysfunction are poo...

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Detalles Bibliográficos
Autores principales: Crewe, Morgan, Madabhushi, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656403/
https://www.ncbi.nlm.nih.gov/pubmed/34899270
http://dx.doi.org/10.3389/fnagi.2021.751742