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Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation
The North American beaver is an exceptionally long-lived and cancer-resistant rodent species. Here, we report the evolutionary changes in its gene coding sequences, copy numbers, and expression. We identify changes that likely increase its ability to detoxify aldehydes, enhance tumor suppression and...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656434/ https://www.ncbi.nlm.nih.gov/pubmed/34758328 http://dx.doi.org/10.1016/j.celrep.2021.109965 |