Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation

The North American beaver is an exceptionally long-lived and cancer-resistant rodent species. Here, we report the evolutionary changes in its gene coding sequences, copy numbers, and expression. We identify changes that likely increase its ability to detoxify aldehydes, enhance tumor suppression and...

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Detalles Bibliográficos
Autores principales: Zhang, Quanwei, Tombline, Gregory, Ablaeva, Julia, Zhang, Lei, Zhou, Xuming, Smith, Zachary, Zhao, Yang, Xiaoli, Alus M., Wang, Zhen, Lin, Jhih-Rong, Jabalameli, M. Reza, Mitra, Joydeep, Nguyen, Nha, Vijg, Jan, Seluanov, Andrei, Gladyshev, Vadim N., Gorbunova, Vera, Zhang, Zhengdong D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656434/
https://www.ncbi.nlm.nih.gov/pubmed/34758328
http://dx.doi.org/10.1016/j.celrep.2021.109965

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