TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle

SIMPLE SUMMARY: A promising anti-cancer compound TH588 has been recently identified as a microtubule-targeting agent that inhibits tubulin polymerization in vitro and interferes with microtubule dynamics in interphase cells. Although it was shown to arrest cells in mitosis, its effect on microtubule...

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Detalles Bibliográficos
Autores principales: Rajendraprasad, Girish, Eibes, Susana, Boldú, Claudia Guasch, Barisic, Marin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657032/
https://www.ncbi.nlm.nih.gov/pubmed/34885104
http://dx.doi.org/10.3390/cancers13235995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657032/
https://www.ncbi.nlm.nih.gov/pubmed/34885104
http://dx.doi.org/10.3390/cancers13235995

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