The MEK/ERK/miR-21 Signaling Is Critical in Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells

SIMPLE SUMMARY: Our study provided data that the inhibition of MEK/ERK signaling could overcome Osimertinib resistance both in vitro and in vivo. Mechanistically, MEK inhibitor Trametinib suppressed the tumorigenic properties of NSCLC cells by reducing the generation of CAFs. The trametinib-mediated...

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Detalles Bibliográficos
Autores principales: Huang, Wen-Chien, Yadav, Vijesh Kumar, Cheng, Wei-Hong, Wang, Chun-Hua, Hsieh, Ming-Shou, Huang, Ting-Yi, Lin, Shiou-Fu, Yeh, Chi-Tai, Kuo, Kuang-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657072/
https://www.ncbi.nlm.nih.gov/pubmed/34885115
http://dx.doi.org/10.3390/cancers13236005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657072/
https://www.ncbi.nlm.nih.gov/pubmed/34885115
http://dx.doi.org/10.3390/cancers13236005

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