Cargando…

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

SIMPLE SUMMARY: Desmoplastic small round cell tumor (DSRCT) is an extremely rare soft tissue sarcoma arising in the abdomen of adolescents and young adults. This sarcoma is driven by a single genomic rearrangement, resulting in the expression of the EWSR1-WT1 fusion gene. No effective treatment exis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bleijs, Margit, Pleijte, Corine, Engels, Sem, Ringnalda, Femke, Meyer-Wentrup, Friederike, van de Wetering, Marc, Clevers, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657306/ https://www.ncbi.nlm.nih.gov/pubmed/34885181 http://dx.doi.org/10.3390/cancers13236072

Ejemplares similares

Xenograft and organoid model systems in cancer research
por: Bleijs, Margit, et al.
Publicado: (2019)

Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells
por: Visser, Lindy L., et al.
Publicado: (2023)

Canine Pituitary Organoids as 3D In Vitro Model for Cushing Disease
por: Sanders, Karin, et al.
Publicado: (2021)

Desmoplastic Small Round Cell Tumor of the Uterus: A Report of Molecularly Confirmed Case with EWSR1-WT1 Fusion
por: Dundr, Pavel, et al.
Publicado: (2022)

Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein
por: Magrath, Justin W., et al.
Publicado: (2022)

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
por: Orth, Martin F., et al.
Publicado: (2020)

Desmoplastic small round cell tumor (DSRCT) xenografts and tissue culture lines: Establishment and initial characterization
por: MARKIDES, CONSTANTINE S.A., et al.
Publicado: (2013)

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
por: García-Domínguez, Daniel J., et al.
Publicado: (2021)

Routine EWS Fusion Analysis in the Oncology Clinic to Identify Cancer-Specific Peptide Sequence Patterns That Span Breakpoints in Ewing Sarcoma and DSRCT
por: Anderson, Peter M., et al.
Publicado: (2023)

Gastroblastoma without GLI1 and EWSR1 gene breaks
por: Gong, Can, et al.
Publicado: (2023)

Intra-Abdominal Desmoplastic Small Round Cell Tumor (DSRCT) and the Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Review
por: Reijers, Sophie J. M., et al.
Publicado: (2023)

Metastatic sporadic paraganglioma with EWSR1::CREM gene fusion: A unique molecular profile that expands the phenotypic diversity of the molecular landscape of the EWSR1::CREM gene fusion positive tumors
por: Javaid, Sehrish, et al.
Publicado: (2022)

Long‐term survivors with desmoplastic small round cell tumor (DSRCT): Results from a retrospective single‐institution case series analysis
por: Giani, Claudia, et al.
Publicado: (2023)

TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization
por: Tannukit, Sissada, et al.
Publicado: (2008)

Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report
por: Ke, Helen, et al.
Publicado: (2021)

Scapular Angiomatoid Fibrous Histiocytoma with EWSR1-CREB1 Fusion in an Adult Patient
por: Kobayashi, Hiroshi, et al.
Publicado: (2021)

Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients
por: Ren, Hezhen, et al.
Publicado: (2021)

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications
por: Yu, Le, et al.
Publicado: (2023)

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype
por: Hanemaaijer, Evelyn S., et al.
Publicado: (2021)

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors
por: Cantile, Monica, et al.
Publicado: (2013)

Adenocarcinoma of the minor salivary gland with concurrent MAML2 and EWSR1 alterations
por: Choi, Sangjoon, et al.
Publicado: (2021)

EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma
por: Lucas, Calixto-Hope G., et al.
Publicado: (2021)

EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B
por: Kim, Haeyoung, et al.
Publicado: (2023)

The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism
por: Kaprio, Heidi, et al.
Publicado: (2023)

Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma
por: Gouda, Mohamed A., et al.
Publicado: (2023)

EWSR1 rearranged primary renal myoepithelial carcinoma: a diagnostic conundrum
por: Nishith, Nilay, et al.
Publicado: (2023)

Gene partners of the EWSR1 fusion may represent molecularly distinct entities
por: Walker, Victoria, et al.
Publicado: (2023)

Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
por: Kretzschmar, Kai, et al.
Publicado: (2021)

Knockdown of EWSR1/FLI1 expression alters the transcriptome of Ewing sarcoma cells in vitro
por: Wang, Jihan, et al.
Publicado: (2016)

Therapeutic Potential of EWSR1–FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma
por: Cervera, Saint T., et al.
Publicado: (2021)

Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
por: Park, Hyewon, et al.
Publicado: (2020)

WT1 peptide analogue WT1-126Y enhances leukemia lysis
por: Alqudaihi, Ghofran, et al.
Publicado: (2014)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
por: Oji, Yusuke, et al.
Publicado: (2016)

Rationale for Early Detection of EWSR1 Translocation-Associated Sarcoma Biomarkers in Liquid Biopsy
por: Clanchy, Felix I. L.
Publicado: (2021)

Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
por: Bodis, Sandor, et al.
Publicado: (2021)

PATH-23. ADULT SPINAL CORD ASTROBLASTOMA WITH EWSR1-BEND2 FUSION
por: Tsutsui, Takeyoshi, et al.
Publicado: (2020)

Splice variants denote differences between a cancer stem cell side population of EWSR1-ERG-based Ewing sarcoma cells, its main population and EWSR1-FLI-based cells
por: Korsching, Eberhard, et al.
Publicado: (2022)

Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression
por: Li, Huanhuan, et al.
Publicado: (2019)

Expanding the spectrum of EWSR1‐PATZ1 rearranged CNS tumors: An infantile case with leptomeningeal dissemination
por: Rossi, Sabrina, et al.
Publicado: (2021)

WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1
por: Lv, Long, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tedtrdhpaegc8j9pe5b3svp9nc