Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation

Triple-negative breast cancer (TNBC) cells overexpress the epidermal growth factor receptor (EGFR). Nuclear EGFR (nEGFR) drives resistance to anti-EGFR therapy and is correlated with poor survival in breast cancer. Inhibition of EGFR nuclear translocation may be a reasonable approach for the treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji-Hyang, Choi, Hack-Sun, Lee, Dong-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657416/
https://www.ncbi.nlm.nih.gov/pubmed/34884765
http://dx.doi.org/10.3390/ijms222312961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657416/
https://www.ncbi.nlm.nih.gov/pubmed/34884765
http://dx.doi.org/10.3390/ijms222312961

Ejemplares similares