Cargando…

Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

The anti-inflammatory role of regulatory B cells (Breg cells) has been associated with IL-35 based on studies of experimental autoimmune uveitis and encephalitis. The role of Breg cells and IL-35(+) Breg cells for type 1 diabetes (T1D) remains to be investigated. We studied PBMCs from T1D subjects a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Zhengkang, Lundin, Sara, Mejia-Cordova, Mariela, Hassani, Imane, Blixt, Martin, Hjelmqvist, Daisy, Lau, Joey, Espes, Daniel, Carlsson, Per-Ola, Sandler, Stellan, Singh, Kailash
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657454/ https://www.ncbi.nlm.nih.gov/pubmed/34884797 http://dx.doi.org/10.3390/ijms222312988

Ejemplares similares

Kinetics of immune cell responses in the multiple low‐dose streptozotocin mouse model of type 1 diabetes
por: Luo, Zhengkang, et al.
Publicado: (2019)

Interleukin-35 administration counteracts established murine type 1 diabetes – possible involvement of regulatory T cells
por: Singh, Kailash, et al.
Publicado: (2015)

Pro-tumoral immune cell alterations in wild type and Shb-deficient mice in response to 4T1 breast carcinomas
por: Li, Xiujuan, et al.
Publicado: (2018)

The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control
por: Singh, Kailash, et al.
Publicado: (2017)

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes
por: Espes, Daniel, et al.
Publicado: (2013)

Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
por: Espes, Daniel, et al.
Publicado: (2011)

Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes
por: Luo, Zhengkang, et al.
Publicado: (2022)

Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
por: Espes, Daniel, et al.
Publicado: (2020)

Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
por: Espes, Daniel, et al.
Publicado: (2014)

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement
por: Liljebäck, Hanna, et al.
Publicado: (2019)

Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
por: Grönberg, Annika, et al.
Publicado: (2020)

Severe diabetic ketoacidosis in combination with starvation and anorexia nervosa at onset of type 1 diabetes: A case report
por: Espes, Daniel, et al.
Publicado: (2013)

Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases
por: Magnusson, Louise, et al.
Publicado: (2020)

Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
por: Grönberg, Annika, et al.
Publicado: (2022)

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice
por: Singh, Kailash, et al.
Publicado: (2015)

Irisin—A Pancreatic Islet Hormone
por: Norman, Daniel, et al.
Publicado: (2022)

Decreased β-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
por: Ullsten, Sara, et al.
Publicado: (2019)

Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice
por: Liljebäck, Hanna, et al.
Publicado: (2019)

Quantification of β-Cell Mass in Intramuscular Islet Grafts Using Radiolabeled Exendin-4
por: Espes, Daniel, et al.
Publicado: (2016)

Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
por: Ullsten, Sara, et al.
Publicado: (2020)

Somatostatin receptor 1–5; expression profiles during rat development
por: Ludvigsen, Eva, et al.
Publicado: (2015)

Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
por: Espes, Daniel, et al.
Publicado: (2022)

Further improvement of our metrics—will plan S affect them?
por: Andersson, Arne, et al.
Publicado: (2019)

Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
por: Magnusson, Louise, et al.
Publicado: (2020)

Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
por: Hill, Henrik, et al.
Publicado: (2021)

The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors
por: He, Qi, et al.
Publicado: (2019)

Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes
por: Singh, K., et al.
Publicado: (2019)

GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
por: Espes, Daniel, et al.
Publicado: (2021)

Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization
por: Henriksnäs, Johanna, et al.
Publicado: (2012)

Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes: a Phase I/II randomised double-blind placebo-controlled trial
por: Carlsson, Per-Ola, et al.
Publicado: (2023)

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
por: Digre, Andreas, et al.
Publicado: (2017)

Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes
por: Katsogiannos, Petros, et al.
Publicado: (2021)

Pancreatic islet blood flow and its measurement
por: Jansson, Leif, et al.
Publicado: (2016)

Diabetic complications and prospective immunotherapy
por: Reynolds, Lewis, et al.
Publicado: (2023)

The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis
por: Omenesa Bello, Ramatu, et al.
Publicado: (2018)

Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo
por: Ludvigsen, Eva, et al.
Publicado: (2011)

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
por: Tian, Geng, et al.
Publicado: (2011)

The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice
por: Anvari, Ebrahim, et al.
Publicado: (2015)

Interleukin-35 as an Emerging Player in Tumor Microenvironment
por: Xue, Wenhua, et al.
Publicado: (2019)

Immunomodulatory cytokine interleukin-35 and immune thrombocytopaenia
por: Zhu, Jing-Jing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_plskdf1siu6dmlf6qkcvv4h0jd