Structural Modelling of KCNQ1 and KCNH2 Double Mutant Proteins, Identified in Two Severe Long QT Syndrome Cases, Reveals New Insights into Cardiac Channelopathies

Congenital long QT syndrome (LQTS) is a cardiac channelopathy characterized by a prolongation of the QT interval and T-wave abnormalities, caused, in most cases, by mutations in KCNQ1, KCNH2, and SCN5A. Although the predominant pattern of LQTS inheritance is autosomal dominant, compound heterozygous...

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Detalles Bibliográficos
Autores principales: Agudelo, William A., Gil-Quiñones, Sebastian Ramiro, Fonseca, Alejandra, Arenas, Alvaro, Castro, Laura, Sierra-Díaz, Diana Carolina, Patarroyo, Manuel A., Laissue, Paul, Suárez, Carlos F., Cabrera, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657475/
https://www.ncbi.nlm.nih.gov/pubmed/34884666
http://dx.doi.org/10.3390/ijms222312861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657475/
https://www.ncbi.nlm.nih.gov/pubmed/34884666
http://dx.doi.org/10.3390/ijms222312861

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