PCSK9 Induces Tissue Factor Expression by Activation of TLR4/NFkB Signaling

Proprotein convertase subtilisin kexin 9 (PCSK9) increases LDL cholesterol (C) concentration by accelerating the hepatic degradation of the LDL receptor (R) thus promoting atherogenesis. The molecule, however, also exerts proinflammatory effects independent of circulating LDL-C by enhancing local cy...

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Detalles Bibliográficos
Autores principales: Scalise, Valentina, Sanguinetti, Chiara, Neri, Tommaso, Cianchetti, Silvana, Lai, Michele, Carnicelli, Vittoria, Celi, Alessandro, Pedrinelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657476/
https://www.ncbi.nlm.nih.gov/pubmed/34884442
http://dx.doi.org/10.3390/ijms222312640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657476/
https://www.ncbi.nlm.nih.gov/pubmed/34884442
http://dx.doi.org/10.3390/ijms222312640

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