Dickkopf-1 Inhibition Reactivates Wnt/β-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo

The Wnt/β-catenin signaling pathway plays a pivotal role during embryogenesis and its deregulation is a key mechanism in the origin and progression of several tumors. Wnt antagonists have been described as key modulators of Wnt/β-catenin signaling in cancer, with Dickkopf-1 (DKK-1) being the most st...

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Detalles Bibliográficos
Autores principales: Giralt, Irina, Gallo-Oller, Gabriel, Navarro, Natalia, Zarzosa, Patricia, Pons, Guillem, Magdaleno, Ainara, Segura, Miguel F., Sábado, Constantino, Hladun, Raquel, Arango, Diego, Sánchez de Toledo, José, Moreno, Lucas, Gallego, Soledad, Roma, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657544/
https://www.ncbi.nlm.nih.gov/pubmed/34884726
http://dx.doi.org/10.3390/ijms222312921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657544/
https://www.ncbi.nlm.nih.gov/pubmed/34884726
http://dx.doi.org/10.3390/ijms222312921

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