Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles

The adipokine Neuregulin 4 (Nrg4) protects against obesity-induced insulin resistance. Here, we analyze how the downregulation of Nrg4 influences insulin action and the underlying mechanisms in adipocytes. Validated shRNA lentiviral vectors were used to generate scramble (Scr) and Nrg4 knockdown (KD...

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Detalles Bibliográficos
Autores principales: Díaz-Sáez, Francisco, Blanco-Sinfreu, Carla, Archilla-Ortega, Adrià, Sebastian, David, Romero, Montserrat, Hernández-Alvarez, Maria Isabel, Mora, Sílvia, Testar, Xavier, Ricart, Wifredo, Fernández-Real, José Manuel, Moreno-Navarrete, José María, Aragonés, Julián, Camps, Marta, Zorzano, Antonio, Gumà, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657571/
https://www.ncbi.nlm.nih.gov/pubmed/34884763
http://dx.doi.org/10.3390/ijms222312960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657571/
https://www.ncbi.nlm.nih.gov/pubmed/34884763
http://dx.doi.org/10.3390/ijms222312960

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