Cargando…

Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site

Organophosphorus hydrolase (OPH) is a metalloenzyme that can hydrolyze organophosphorus agents resulting in products that are generally of reduced toxicity. The best OPH substrate found to date is diethyl p-nitrophenyl phosphate (paraoxon). Most structural and kinetic studies assume that the binding...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Khoury, Léa, Mobley, David L., Ye, Dongmei, Rempe, Susan B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657610/ https://www.ncbi.nlm.nih.gov/pubmed/34884430 http://dx.doi.org/10.3390/ijms222312624

Ejemplares similares

Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
por: Magnin, Geraldine, et al.
Publicado: (2019)

Optical Detection of Paraoxon Using Single-Walled Carbon Nanotube Films with Attached Organophosphorus Hydrolase-Expressed Escherichia coli
por: Kim, Intae, et al.
Publicado: (2015)

Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP)
por: Li, Dandan, et al.
Publicado: (2017)

Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning
por: Eddleston, Michael, et al.
Publicado: (2019)

Fluorescent Silicate Materials for the Detection of Paraoxon
por: Johnson, Brandy J., et al.
Publicado: (2010)

Combined Pre- and Posttreatment of Paraoxon Exposure
por: Lorke, Dietrich E, et al.
Publicado: (2020)

Genomic and Phenotypic Alterations of the Neuronal-Like Cells Derived from Human Embryonal Carcinoma Stem Cells (NT2) Caused by Exposure to Organophosphorus Compounds Paraoxon and Mipafox
por: Pamies, David, et al.
Publicado: (2014)

The Cytoplasmic and Periplasmic Expression Levels and Folding of Organophosphorus Hydrolase Enzyme in Escherichia coli
por: Latifi, Ali Mohammad, et al.
Publicado: (2015)

Enzymatic decontamination of paraoxon-ethyl limits long-term effects in planarians
por: Poirier, Laetitia, et al.
Publicado: (2020)

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
por: Kuca, Kamil, et al.
Publicado: (2009)

Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication
por: Sobolev, Vladislav E., et al.
Publicado: (2021)

A Butyrylcholinesterase Camera Biosensor Tested for Carbofuran and Paraoxon Assay
por: Pohanka, Miroslav, et al.
Publicado: (2022)

The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro
por: Golderman, Valery, et al.
Publicado: (2016)

In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
por: Kitagawa, Daniel A. S., et al.
Publicado: (2019)

Improvement in organophosphorus hydrolase activity of cell surface-engineered yeast strain using Flo1p anchor system
por: Fukuda, Takeshi, et al.
Publicado: (2010)

Comparison of the Respiratory Toxicity and Total Cholinesterase Activities in Dimethyl Versus Diethyl Paraoxon-Poisoned Rats
por: Houzé, Pascal, et al.
Publicado: (2019)

Determination of Picomolar Concentrations of Paraoxon in Human Urine by Fluorescence-Based Enzymatic Assay
por: Cetrangolo, Giovanni Paolo, et al.
Publicado: (2019)

Study on Spontaneous Reactivation and Aging of Acetylcholinesterase Inhibited by Paraoxon and Malaoxon in Ten Species
por: Gao, Mingwei, et al.
Publicado: (2023)

Predicting binding sites of hydrolase-inhibitor complexes by combining several methods
por: Sen, Taner Z, et al.
Publicado: (2004)

Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning
por: Pang, Li, et al.
Publicado: (2019)

Simultaneous molecular docking of different ligands to His(6)-tagged organophosphorus hydrolase as an effective tool for assessing their effect on the enzyme
por: Aslanli, Aysel, et al.
Publicado: (2019)

Temperature artifacts in protein structures bias ligand-binding predictions
por: Bradford, Shanshan Y. C., et al.
Publicado: (2021)

Electrochemical detection of methyl-paraoxon based on bifunctional cerium oxide nanozyme with catalytic activity and signal amplification effect
por: Sun, Yuzhou, et al.
Publicado: (2021)

The Effect of Conformational Variability of Phosphotriesterase upon N-acyl-L-homoserine Lactone and Paraoxon Binding: Insights from Molecular Dynamics Studies
por: Zhan, Dongling, et al.
Publicado: (2013)

The lesion site of organophosphorus-induced central apnea and the effects of antidotes
por: Nomura, Kazuhito, et al.
Publicado: (2023)

Organophosphorus chemistry
por: Hanson, Paul R
Publicado: (2014)

Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon
por: de Paula, Reuel L., et al.
Publicado: (2018)

A FRET Approach to Detect Paraoxon among Organophosphate Pesticides Using a Fluorescent Biosensor
por: Rodrigues, Andreia C. M., et al.
Publicado: (2022)

Muscarinic M(1) receptor and cannabinoid CB(1) receptor do not modulate paraoxon-induced seizures
por: Kow, Rebecca L, et al.
Publicado: (2015)

Catalytic residues in hydrolases: analysis of methods designed for ligand-binding site prediction
por: Prymula, Katarzyna, et al.
Publicado: (2010)

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity
por: Bright, Nicholas A., et al.
Publicado: (2016)

Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study
por: Nurulain, Syed M., et al.
Publicado: (2015)

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
por: Kuca, Kamil, et al.
Publicado: (2018)

Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats
por: Kayouka, Maya, et al.
Publicado: (2020)

Interaction of Cucurbit[7]uril with Oxime K027, Atropine, and Paraoxon: Risky or Advantageous Delivery System?
por: Zdarova Karasova, Jana, et al.
Publicado: (2020)

Highly Selective Detection of Paraoxon in Food Based on the Platform of Cu Nanocluster/MnO(2) Nanosheets
por: Liu, Shuo, et al.
Publicado: (2022)

Organophosphorus Insecticide Poisoning
Publicado: (1999)

Organophosphorus Chemistry 2021
por: Keglevich, György
Publicado: (2023)

Mechanical Bond Approach to Introducing Self-Adaptive Active Sites in Covalent Organic Frameworks for Zinc-Catalyzed Organophosphorus Degradation
por: Ruan, Xianghui, et al.
Publicado: (2021)

Enzymatic degradation of organophosphorus insecticides decreases toxicity in planarians and enhances survival
por: Poirier, Laetitia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fu0tnnbid804gqb36oaidds81d