Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas

Activation-induced deaminase (AID) is required for somatic hypermutation in immunoglobulin genes, but also induces off-target mutations. Follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), the most frequent types of indolent B-cell tumors, are exposed to AID activity during lymphomagene...

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Detalles Bibliográficos
Autores principales: Sepulveda-Yanez, Julieta H., Alvarez-Saravia, Diego, Fernandez-Goycoolea, Jose, Aldridge, Jacqueline, van Bergen, Cornelis A. M., Posthuma, Ward, Uribe-Paredes, Roberto, Veelken, Hendrik, Navarrete, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657711/
https://www.ncbi.nlm.nih.gov/pubmed/34884820
http://dx.doi.org/10.3390/ijms222313015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657711/
https://www.ncbi.nlm.nih.gov/pubmed/34884820
http://dx.doi.org/10.3390/ijms222313015

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