Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase

The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ability of the cellular protein quality control system to clear these intermediat...

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Detalles Bibliográficos
Autores principales: Franco, Aitor, Cuéllar, Jorge, Fernández-Higuero, José Ángel, de la Arada, Igor, Orozco, Natalia, Valpuesta, José M., Prado, Adelina, Muga, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657883/
https://www.ncbi.nlm.nih.gov/pubmed/34884786
http://dx.doi.org/10.3390/ijms222312983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657883/
https://www.ncbi.nlm.nih.gov/pubmed/34884786
http://dx.doi.org/10.3390/ijms222312983

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