Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density

PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. PSD-95 levels are reduced during aging and in neurodegenerative diseases like Huntington’s disease (HD), and it is believed to contribute to synaptic dysfunction and behavioral...

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Detalles Bibliográficos
Autores principales: Zarate, Nicole, Intihar, Taylor A., Yu, Dahyun, Sawyer, Jacob, Tsai, Wei, Syed, Maha, Carlson, Luke, Gomez-Pastor, Rocio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657899/
https://www.ncbi.nlm.nih.gov/pubmed/34884918
http://dx.doi.org/10.3390/ijms222313113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657899/
https://www.ncbi.nlm.nih.gov/pubmed/34884918
http://dx.doi.org/10.3390/ijms222313113

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