A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling

Protein tyrosine phosphatase 1B (PTP1B) is a critical negative modulator of insulin signaling and has attracted considerable attention in treating type 2 diabetes mellitus (T2DM). Low-molecular-weight polymannuronic acid phosphate (LPMP) was found to be a selective PTP1B inhibitor with an IC(50) of...

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Detalles Bibliográficos
Autores principales: Li, Dan, Zhang, Shuai, Yang, Cheng, Li, Quancai, Wang, Shixin, Xu, Ximing, Hao, Jiejie, Li, Chunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657924/
https://www.ncbi.nlm.nih.gov/pubmed/34884501
http://dx.doi.org/10.3390/ijms222312693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657924/
https://www.ncbi.nlm.nih.gov/pubmed/34884501
http://dx.doi.org/10.3390/ijms222312693

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