Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP(3)R) Inhibitors in Cancer
Inositol 1, 4, 5-trisphosphate receptor (IP(3)R)-mediated Ca(2+) signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death. Remodeling Ca(2+) signals by targeting the downstream effectors is considered an important hallmark in cancer progression. Des...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657927/ https://www.ncbi.nlm.nih.gov/pubmed/34884798 http://dx.doi.org/10.3390/ijms222312993 |