Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP(3)R) Inhibitors in Cancer

Inositol 1, 4, 5-trisphosphate receptor (IP(3)R)-mediated Ca(2+) signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death. Remodeling Ca(2+) signals by targeting the downstream effectors is considered an important hallmark in cancer progression. Des...

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Detalles Bibliográficos
Autores principales: Ismatullah, Humaira, Jabeen, Ishrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657927/
https://www.ncbi.nlm.nih.gov/pubmed/34884798
http://dx.doi.org/10.3390/ijms222312993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657927/
https://www.ncbi.nlm.nih.gov/pubmed/34884798
http://dx.doi.org/10.3390/ijms222312993

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