Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the ‘Regulatory Loop’

The nonsense-mediated mRNA decay (NMD) pathway rapidly detects and degrades mRNA containing premature termination codons (PTCs). UP-frameshift 1 (UPF1), the master regulator of the NMD process, has two alternatively-spliced isoforms; one carries 353-GNEDLVIIWLR-363 insertion in the ‘regulatory loop...

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Detalles Bibliográficos
Autores principales: Padariya, Monikaben, Fahraeus, Robin, Hupp, Ted, Kalathiya, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657986/
https://www.ncbi.nlm.nih.gov/pubmed/34884553
http://dx.doi.org/10.3390/ijms222312744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657986/
https://www.ncbi.nlm.nih.gov/pubmed/34884553
http://dx.doi.org/10.3390/ijms222312744

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