Viral Transduction of Human Rod Opsin or Channelrhodopsin Variants to Mouse ON Bipolar Cells Does Not Impact Retinal Anatomy or Cause Measurable Death in the Targeted Cells

The viral gene delivery of optogenetic actuators to the surviving inner retina has been proposed as a strategy for restoring vision in advanced retinal degeneration. We investigated the safety of ectopic expression of human rod opsin (hRHO), and two channelrhodopsins (enhanced sensitivity CoChR-3M a...

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Detalles Bibliográficos
Autores principales: Wright, Phillip, Rodgers, Jessica, Wynne, Jonathan, Bishop, Paul N., Lucas, Robert J., Milosavljevic, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658283/
https://www.ncbi.nlm.nih.gov/pubmed/34884916
http://dx.doi.org/10.3390/ijms222313111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658283/
https://www.ncbi.nlm.nih.gov/pubmed/34884916
http://dx.doi.org/10.3390/ijms222313111

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