An Efficient Approach to 2-CF(3)-Indoles Based on ortho-Nitrobenzaldehydes

The catalytic olefination reaction of 2-nitrobenzaldehydes with CF(3)CCl(3) afforded stereoselectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF(3)-β-(2-nitroaryl) enamines. Subsequent one pot reduction of n...

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Detalles Bibliográficos
Autores principales: Muzalevskiy, Vasiliy M., Sizova, Zoia A., Abaev, Vladimir T., Nenajdenko, Valentine G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658784/
https://www.ncbi.nlm.nih.gov/pubmed/34885948
http://dx.doi.org/10.3390/molecules26237365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658784/
https://www.ncbi.nlm.nih.gov/pubmed/34885948
http://dx.doi.org/10.3390/molecules26237365

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