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An Efficient Approach to 2-CF(3)-Indoles Based on ortho-Nitrobenzaldehydes
The catalytic olefination reaction of 2-nitrobenzaldehydes with CF(3)CCl(3) afforded stereoselectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF(3)-β-(2-nitroaryl) enamines. Subsequent one pot reduction of n...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658784/ https://www.ncbi.nlm.nih.gov/pubmed/34885948 http://dx.doi.org/10.3390/molecules26237365 |