Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands

Histone deacetylases (HDACs) play important roles in cell growth, cell differentiation, cell apoptosis, and many other cellular processes. The inhibition of different classes of HDACs has been shown to be closely related to the therapy of cancers and other diseases. In this study, a series of novel...

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Detalles Bibliográficos
Autores principales: Lu, Yingxin, Sun, Danwen, Xiao, Donghuai, Shao, Yingying, Su, Mingbo, Zhou, Yubo, Li, Jia, Zhu, Shulei, Lu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658794/
https://www.ncbi.nlm.nih.gov/pubmed/34885822
http://dx.doi.org/10.3390/molecules26237241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658794/
https://www.ncbi.nlm.nih.gov/pubmed/34885822
http://dx.doi.org/10.3390/molecules26237241

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