Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas

Isolated from the marine bacteria Serinicoccus sp., seriniquinone (SQ1) has been characterized by its selective activity in melanoma cell lines marked by its modulation of human dermcidin and induction of autophagy and apoptosis. While an active lead, the lack of solubility of SQ1 in both organic an...

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Detalles Bibliográficos
Autores principales: Hirata, Amanda S., Rezende-Teixeira, Paula, Machado-Neto, João Agostinho, Jimenez, Paula C., Clair, James J. La, Fenical, William, Costa-Lotufo, Leticia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658889/
https://www.ncbi.nlm.nih.gov/pubmed/34885944
http://dx.doi.org/10.3390/molecules26237362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658889/
https://www.ncbi.nlm.nih.gov/pubmed/34885944
http://dx.doi.org/10.3390/molecules26237362

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