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Organometallic small molecule kinase inhibitors – direct incorporation of Re and (99m)Tc into Opaganib®
[(η5-Cp)Re(I)(CO)(3)] was incorporated into the kinase inhibitor Opaganib®. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib® against PC-3 cancer cells. The IC(50) value for the kinase SK2 is 30x higher than that of Opaganib®. The (99m)Tc homologue was synthe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658909/ https://www.ncbi.nlm.nih.gov/pubmed/34817478 http://dx.doi.org/10.1039/d1cc03678e |