Cargando…

Organometallic small molecule kinase inhibitors – direct incorporation of Re and (99m)Tc into Opaganib®

[(η5-Cp)Re(I)(CO)(3)] was incorporated into the kinase inhibitor Opaganib®. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib® against PC-3 cancer cells. The IC(50) value for the kinase SK2 is 30x higher than that of Opaganib®. The (99m)Tc homologue was synthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lengacher, Raphael, Wang, Youchao, Braband, Henrik, Blacque, Olivier, Gasser, Gilles, Alberto, Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658909/ https://www.ncbi.nlm.nih.gov/pubmed/34817478 http://dx.doi.org/10.1039/d1cc03678e

Ejemplares similares

From Tc(VII) to Tc(I); facile syntheses of bis-arene complexes [(99(m))Tc(arene)(2)](+) from pertechnetate
por: Benz, Michael, et al.
Publicado: (2015)

One Electron Changes Everything: Synthesis, Characterization, and Reactivity Studies of [Re(NCCH(3))(6)](3+)
por: Bolliger, Robin, et al.
Publicado: (2022)

Binding Small Molecules to a cis-Dicarbonyl (99)Tc(I)-PNP Complex via Metal–Ligand Cooperativity
por: Besmer, Manuel Luca, et al.
Publicado: (2023)

Introduction of Re(CO)(3)(+)/(99m)Tc(CO)(3)(+) Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers
por: Gorshkov, Nikolay Ivanovich, et al.
Publicado: (2021)

Naphthalene Exchange in [Re(η(6)‐napht)(2)](+) with Pharmaceuticals Leads to Highly Functionalized Sandwich Complexes [M(η(6)‐pharm)(2)](+) (M=Re/(99m)Tc)
por: Nadeem, Qaisar, et al.
Publicado: (2021)

Recent Progress in the Development of Opaganib for the Treatment of Covid-19
por: Smith, Charles D, et al.
Publicado: (2022)

Organometallic Anticancer Compounds
por: Gasser, Gilles, et al.
Publicado: (2010)

Exploring Rhenium Arene Piano-Stool Chemistry with [Re(η(6)-C(6)H(6))(NCCH(3))(3)](+): A Powerful Semi-Solvated Precursor
por: Bolliger, Robin, et al.
Publicado: (2023)

The Sphingosine Kinase 2 Inhibitor Opaganib Protects Against Acute Kidney Injury in Mice
por: Maines, Lynn W, et al.
Publicado: (2022)

Opaganib Protects against Radiation Toxicity: Implications for Homeland Security and Antitumor Radiotherapy
por: Maines, Lynn W., et al.
Publicado: (2022)

Poor Tc-99m dimercaptosuccinic acid uptake, re-evaluation with Tc-99m MAG3 scintigraphy in Lowe syndrome
por: Koca, Gokhan, et al.
Publicado: (2011)

Comparison of [(99m)Tc]Tc-tilmanocept with [(99m)Tc]Tc-sulphur colloids and [(99m)Tc]Tc-albumin colloids for sentinel lymph node detection in patients with cutaneous malignancies of the head
por: Ooms, Mark, et al.
Publicado: (2022)

Clinical usefulness of (99m)Tc-HYNIC-TOC, (99m)Tc(V)-DMSA, and (99m)Tc-MIBI SPECT in the evaluation of pituitary adenomas
por: Vukomanovic, Vladimir R., et al.
Publicado: (2019)

Head to head comparison of [(99m)Tc]Tc(CO)(3)(NTA) and [(99m)Tc]Tc-MAG3 in patients with suspected obstruction
por: Taylor, Andrew T., et al.
Publicado: (2021)

Opaganib in Coronavirus Disease 2019 Pneumonia: Results of a Randomized, Placebo-Controlled Phase 2a Trial
por: Winthrop, Kevin L, et al.
Publicado: (2022)

Pharmacokinetics of the phosphatidylserine tracers (99m)Tc-lactadherin and (99m)Tc-annexin V in pigs
por: Poulsen, Runa H, et al.
Publicado: (2013)

Altered [(99m)Tc]Tc-MDP biodistribution from neutron activation sourced (99)Mo
por: Demeter, Sandor, et al.
Publicado: (2018)

Re and (99m)Tc complexes of BodP(3) – multi-modality imaging probes()
por: Davies, Laura H., et al.
Publicado: (2014)

Sentinel lymph node detection in oral cancer: a within-patient comparison between [(99m)Tc]Tc-tilmanocept and [(99m)Tc]Tc-nanocolloid
por: den Toom, Inne J., et al.
Publicado: (2020)

Comparing (99m)Tc-PSMA to (99m)Tc-MDP in Prostate Cancer Staging of the Skeletal System
por: Kabunda, Joseph, et al.
Publicado: (2021)

Editorial for “Organometallic Chemistry” Section, in Journal Molecules
por: Szostak, Michal
Publicado: (2020)

Understanding adsorption geometry of organometallic molecules on graphite
por: Oh, Seungtaek, et al.
Publicado: (2021)

Synthesis of armchair graphene nanoribbons from the 10,10′-dibromo-9,9′-bianthracene molecules on Ag(111): the role of organometallic intermediates
por: Simonov, K. A., et al.
Publicado: (2018)

(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
por: Hayakawa, Takehito, et al.
Publicado: (2018)

(99m)Tc-besilesomab (Scintimun®) in peripheral osteomyelitis: comparison with (99m)Tc-labelled white blood cells
por: Richter, Wolf S., et al.
Publicado: (2011)

Study of Binding Kinetics and Specificity of (99m)Tc-SSS-Complex and (99m)Tc-HMPAO to Blood Cells
por: Auletta, S., et al.
Publicado: (2018)

(99m)Tc-Radiolabeled TPGS Nanomicelles Outperform (99m)Tc-Sestamibi as Breast Cancer Imaging Agent
por: Tesan, Fiorella C., et al.
Publicado: (2019)

An organometallic structure-activity relationship study reveals the essential role of a Re(CO)(3) moiety in the activity against gram-positive pathogens including MRSA
por: Patra, Malay, et al.
Publicado: (2015)

Impeding (99)Tc(IV) mobility in novel waste forms
por: Lee, Mal-Soon, et al.
Publicado: (2016)

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes
por: Schoch, Silvia, et al.
Publicado: (2022)

Anaphylactic Reaction to Tc-99m Macrosalb
por: Schreuder, Nanno, et al.
Publicado: (2019)

Diagnostic accuracy of [(99m)Tc]Tc-Sestamibi in the assessment of thyroid nodules
por: Yordanova, Anna, et al.
Publicado: (2017)

Imaging Hydrogen Sulfide in Hypoxic Tissue with [(99m)Tc]Tc-Gluconate
por: Kweon, Yongkyoung, et al.
Publicado: (2020)

Magnesium-Molybate Compounds as Matrix for (99)Mo/(99m)Tc Generators
por: Monroy-Guzman, Fabiola, et al.
Publicado: (2011)

Bone turnover markers are correlated with total skeletal uptake of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP)
por: Lenora, Janaka, et al.
Publicado: (2009)

Comparison of Tc-99m pertechnetate images with dual-phase Tc 99m MIBI and SPECT images in primary hyperparathyroidism
por: Sager, Sait, et al.
Publicado: (2014)

Evaluation of interobserver variability of parenchymal phase of Tc-99m mercaptoacetyltriglycine and Tc-99m dimercaptosuccinic acid renal scintigraphy
por: Erdoğan, Zeynep, et al.
Publicado: (2014)

Comparison of [(99m)Tc]Tilmanocept and Filtered [(99m)Tc]Sulfur Colloid for Identification of SLNs in Breast Cancer Patients
por: Baker, Jennifer L., et al.
Publicado: (2014)

Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children
por: Çelik, Tanju, et al.
Publicado: (2014)

Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer
por: O’Connor, Michael K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vtvknpc1b9i53eid8p0f7df3cf