Synthesis, Biological Evaluation, and Structure–Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis

The aliphatic heterocycles piperidine and morpholine are core structures of well-known antifungals such as fenpropidin and fenpropimorph, commonly used as agrofungicides, and the related morpholine amorolfine is approved for the treatment of dermal mycoses in humans. Inspired by these lead structure...

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Detalles Bibliográficos
Autores principales: Krauß, Jürgen, Müller, Christoph, Klimt, Monika, Valero, Leandro Jorquera, Martínez, José Francisco, Müller, Martin, Bartel, Karin, Binder, Ulrike, Bracher, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658910/
https://www.ncbi.nlm.nih.gov/pubmed/34885791
http://dx.doi.org/10.3390/molecules26237208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658910/
https://www.ncbi.nlm.nih.gov/pubmed/34885791
http://dx.doi.org/10.3390/molecules26237208

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