Identification of Influenza PA(N) Endonuclease Inhibitors via 3D-QSAR Modeling and Docking-Based Virtual Screening

Structural and biochemical studies elucidate that PA(N) may contribute to the host protein shutdown observed during influenza A infection. Thus, inhibition of the endonuclease activity of viral RdRP is an attractive approach for novel antiviral therapy. In order to envisage structurally diverse nove...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Xiang, Junjie, Xie, Qian, Zhao, Jing, Zhang, Hong, Huang, Erfang, Shaw, Pangchui, Liu, Xiaoping, Hu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659138/
https://www.ncbi.nlm.nih.gov/pubmed/34885710
http://dx.doi.org/10.3390/molecules26237129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659138/
https://www.ncbi.nlm.nih.gov/pubmed/34885710
http://dx.doi.org/10.3390/molecules26237129

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