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Identification of Influenza PA(N) Endonuclease Inhibitors via 3D-QSAR Modeling and Docking-Based Virtual Screening
Structural and biochemical studies elucidate that PA(N) may contribute to the host protein shutdown observed during influenza A infection. Thus, inhibition of the endonuclease activity of viral RdRP is an attractive approach for novel antiviral therapy. In order to envisage structurally diverse nove...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659138/ https://www.ncbi.nlm.nih.gov/pubmed/34885710 http://dx.doi.org/10.3390/molecules26237129 |