Continuous Flow Synthesis of Propofol

Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkyla...

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Detalles Bibliográficos
Autores principales: Mougeot, Romain, Jubault, Philippe, Legros, Julien, Poisson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659244/
https://www.ncbi.nlm.nih.gov/pubmed/34885756
http://dx.doi.org/10.3390/molecules26237183
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author Mougeot, Romain
Jubault, Philippe
Legros, Julien
Poisson, Thomas
author_facet Mougeot, Romain
Jubault, Philippe
Legros, Julien
Poisson, Thomas
author_sort Mougeot, Romain
collection PubMed
description Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.
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spelling pubmed-86592442021-12-10 Continuous Flow Synthesis of Propofol Mougeot, Romain Jubault, Philippe Legros, Julien Poisson, Thomas Molecules Communication Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow. MDPI 2021-11-26 /pmc/articles/PMC8659244/ /pubmed/34885756 http://dx.doi.org/10.3390/molecules26237183 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Mougeot, Romain
Jubault, Philippe
Legros, Julien
Poisson, Thomas
Continuous Flow Synthesis of Propofol
title Continuous Flow Synthesis of Propofol
title_full Continuous Flow Synthesis of Propofol
title_fullStr Continuous Flow Synthesis of Propofol
title_full_unstemmed Continuous Flow Synthesis of Propofol
title_short Continuous Flow Synthesis of Propofol
title_sort continuous flow synthesis of propofol
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659244/
https://www.ncbi.nlm.nih.gov/pubmed/34885756
http://dx.doi.org/10.3390/molecules26237183
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