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The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations

Diploid organisms contain a maternal and a paternal genome complement that is thought to provide robustness and allow developmental progression despite genetic perturbations that occur in heterozygosity. However, changes affecting gene dosage from the chromosome down to the individual gene level pos...

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Detalles Bibliográficos
Autores principales: Basilicata, M. Felicia, Keller Valsecchi, Claudia Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659298/
https://www.ncbi.nlm.nih.gov/pubmed/34882671
http://dx.doi.org/10.1371/journal.pgen.1009906