Identification of enzymes that have helminth-specific active sites and are required for Rhodoquinone-dependent metabolism as targets for new anthelmintics

Soil transmitted helminths (STHs) are major human pathogens that infect over a billion people. Resistance to current anthelmintics is rising and new drugs are needed. Here we combine multiple approaches to find druggable targets in the anaerobic metabolic pathways STHs need to survive in their mamma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lautens, Margot J., Tan, June H., Serrat, Xènia, Del Borrello, Samantha, Schertzberg, Michael R., Fraser, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659336/
https://www.ncbi.nlm.nih.gov/pubmed/34843467
http://dx.doi.org/10.1371/journal.pntd.0009991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659336/
https://www.ncbi.nlm.nih.gov/pubmed/34843467
http://dx.doi.org/10.1371/journal.pntd.0009991

Ejemplares similares