Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A

The UNC-104/KIF1A motor is crucial for axonal transport of synaptic vesicles, but how the UNC-104/KIF1A motor is activated in vivo is not fully understood. Here, we identified point mutations located in the motor domain or the inhibitory CC1 domain, which resulted in gain-of-function alleles of unc-...

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Detalles Bibliográficos
Autores principales: Cong, Dezi, Ren, Jinqi, Zhou, Yurong, Wang, Shuang, Liang, Jingjing, Ding, Mei, Feng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659337/
https://www.ncbi.nlm.nih.gov/pubmed/34843479
http://dx.doi.org/10.1371/journal.pgen.1009940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659337/
https://www.ncbi.nlm.nih.gov/pubmed/34843479
http://dx.doi.org/10.1371/journal.pgen.1009940

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