A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, but the picture of Vpu’s itinerary and activities within memb...

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Detalles Bibliográficos
Autores principales: Stoneham, Charlotte A., Langer, Simon, De Jesus, Paul D., Wozniak, Jacob M., Lapek, John, Deerinck, Thomas, Thor, Andrea, Pache, Lars, Chanda, Sumit K., Gonzalez, David J., Ellisman, Mark, Guatelli, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659692/
https://www.ncbi.nlm.nih.gov/pubmed/34843601
http://dx.doi.org/10.1371/journal.ppat.1009409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659692/
https://www.ncbi.nlm.nih.gov/pubmed/34843601
http://dx.doi.org/10.1371/journal.ppat.1009409

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