Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR

ERBB3 has gained attention as a potential therapeutic target to treat colorectal and other types of cancers. To confirm a previous study showing intestinal polyps are dependent upon ERBB3, we generated an intestinal epithelia-specific ERBB3 deletion in C57BL/6-Apc(Min/+) mice. Contrary to the previo...

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Detalles Bibliográficos
Autores principales: Mantilla Rojas, Carolina, McGill, Michael P., Salvador, Anna C., Bautz, David, Threadgill, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659709/
https://www.ncbi.nlm.nih.gov/pubmed/34843459
http://dx.doi.org/10.1371/journal.pgen.1009931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659709/
https://www.ncbi.nlm.nih.gov/pubmed/34843459
http://dx.doi.org/10.1371/journal.pgen.1009931

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