HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

Background: Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder and the decreased number and immunosuppressive dysfunction of Treg cells are key promoters of ITP. However, their mechanisms in ITP development have not been fully clarified. Methods: HUWE1 mRNA and protein levels i...

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Detalles Bibliográficos
Autores principales: Li, Jianqin, Xia, Yalin, Fan, Xiaoru, Wu, Xiaofang, Yang, Feiyun, Hu, Shaoyan, Wang, Zhaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660631/
https://www.ncbi.nlm.nih.gov/pubmed/34900980
http://dx.doi.org/10.3389/fcell.2021.708562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660631/
https://www.ncbi.nlm.nih.gov/pubmed/34900980
http://dx.doi.org/10.3389/fcell.2021.708562

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