Cargando…

Structure of the human SAGA coactivator complex

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been reported, there are noteworthy functional and compositional differences for this complex in metazoans. Here we present the cryog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herbst, Dominik A., Esbin, Meagan N., Louder, Robert K., Dugast-Darzacq, Claire, Dailey, Gina M., Fang, Qianglin, Darzacq, Xavier, Tjian, Robert, Nogales, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660637/ https://www.ncbi.nlm.nih.gov/pubmed/34811519 http://dx.doi.org/10.1038/s41594-021-00682-7

Ejemplares similares

Simple, Inexpensive RNA Isolation and One‐Step RT‐qPCR Methods for SARS‐CoV‐2 Detection and General Use
por: Graham, Thomas G.W., et al.
Publicado: (2021)

Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection
por: Graham, Thomas G. W., et al.
Publicado: (2021)

Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection
por: Esbin, Meagan N., et al.
Publicado: (2020)

Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted photoactivation (PAPA)
por: Graham, Thomas GW, et al.
Publicado: (2022)

Mechanisms governing target search and binding dynamics of hypoxia-inducible factors
por: Chen, Yu, et al.
Publicado: (2022)

Weak multivalent biomolecular interactions: a strength versus numbers tug of war with implications for phase partitioning
por: Darzacq, Xavier, et al.
Publicado: (2022)

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization
por: Collombet, Samuel, et al.
Publicado: (2023)

Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging
por: Dahal, Liza, et al.
Publicado: (2023)

Structure of transcription coactivator SAGA
por: Wang, Haibo, et al.
Publicado: (2020)

Recent evidence that TADs and chromatin loops are dynamic structures
por: Hansen, Anders S., et al.
Publicado: (2017)

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells
por: Hollerer, Ina, et al.
Publicado: (2019)

SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent
por: Adamus, Klaudia, et al.
Publicado: (2021)

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation
por: McSwiggen, David Trombley, et al.
Publicado: (2019)

Cryo-EM structure of human SAGA transcriptional coactivator complex
por: Zhang, Yuzhu, et al.
Publicado: (2022)

Recovering mixtures of fast-diffusing states from short single-particle trajectories
por: Heckert, Alec, et al.
Publicado: (2022)

p300 Is an Obligate Integrator of Combinatorial Transcription Factor Inputs
por: Ferrie, John J., et al.
Publicado: (2023)

Transcription activation depends on the length of the RNA polymerase II C‐terminal domain
por: Sawicka, Anna, et al.
Publicado: (2021)

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
por: McSwiggen, David T., et al.
Publicado: (2019)

Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms
por: Chen, Ying-Jiun C., et al.
Publicado: (2021)

Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors
por: Maurer, Anna C., et al.
Publicado: (2023)

CTCF and cohesin regulate chromatin loop stability with distinct dynamics
por: Hansen, Anders S, et al.
Publicado: (2017)

Guided nuclear exploration increases CTCF target search efficiency
por: Hansen, Anders S., et al.
Publicado: (2019)

The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication
por: Karr, Jonathan P., et al.
Publicado: (2022)

Dynamic modules of the coactivator SAGA in eukaryotic transcription
por: Cheon, Youngseo, et al.
Publicado: (2020)

A dynamic mode of mitotic bookmarking by transcription factors
por: Teves, Sheila S, et al.
Publicado: (2016)

A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes
por: Teves, Sheila S, et al.
Publicado: (2018)

Single-molecule tracking (SMT): a window into live-cell transcription biochemistry
por: Dahal, Liza, et al.
Publicado: (2023)

Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher
por: Normanno, Davide, et al.
Publicado: (2015)

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
por: Hsieh, Tsung-Han S., et al.
Publicado: (2022)

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA
por: Donczew, Rafal, et al.
Publicado: (2020)

Robust model-based analysis of single-particle tracking experiments with Spot-On
por: Hansen, Anders S, et al.
Publicado: (2018)

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription
por: Bonnet, Jacques, et al.
Publicado: (2014)

Determining cellular CTCF and cohesin abundances to constrain 3D genome models
por: Cattoglio, Claudia, et al.
Publicado: (2019)

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus
por: Izeddin, Ignacio, et al.
Publicado: (2014)

Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
por: Cheung, Alan C. M., et al.
Publicado: (2018)

Involvement of the SAGA and TFIID coactivator complexes in transcriptional dysregulation caused by the separation of core and tail Mediator modules
por: Saleh, Moustafa M, et al.
Publicado: (2022)

ATAC and SAGA coactivator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct
por: Yayli, Gizem, et al.
Publicado: (2023)

The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells
por: Fong, Yick W, et al.
Publicado: (2014)

Structural dynamics and DNA interaction of human TFIID
por: Nogales, Eva, et al.
Publicado: (2016)

The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants
por: Vlachonasios, Konstantinos, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r6gkqd0mjc69er2fgti43df6r4