A novel amplification gene PCI domain containing 2 (PCID2) promotes colorectal cancer through directly degrading a tumor suppressor promyelocytic leukemia (PML)

Using whole genome sequencing, PCI Domain Containing 2 (PCID2) was identified to be amplified in colorectal cancer (CRC). In this study, we investigated the expression, biological function, molecular mechanism, and clinical implication of PCID2 in CRC. PCID2 mRNA and protein expression were higher i...

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Detalles Bibliográficos
Autores principales: Zhang, Jingwan, Zhai, Jianning, Wong, Chi Chun, Chen, Huarong, Wang, Xiaohong, Ji, Jiafu, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660639/
https://www.ncbi.nlm.nih.gov/pubmed/34625711
http://dx.doi.org/10.1038/s41388-021-01941-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660639/
https://www.ncbi.nlm.nih.gov/pubmed/34625711
http://dx.doi.org/10.1038/s41388-021-01941-z

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