Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response

cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I interferons. Although cGAS has been considered a traditi...

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Detalles Bibliográficos
Autores principales: Ma, Yuying, Wang, Xiaohui, Luo, Weisheng, Xiao, Ji, Song, Xiaowei, Wang, Yifei, Shuai, Hanlin, Ren, Zhe, Wang, Yiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660693/
https://www.ncbi.nlm.nih.gov/pubmed/34899698
http://dx.doi.org/10.3389/fimmu.2021.741599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660693/
https://www.ncbi.nlm.nih.gov/pubmed/34899698
http://dx.doi.org/10.3389/fimmu.2021.741599

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