IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes

AIMS/HYPOTHESIS: Type 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and if so, (2) what are the key transcriptional drive...

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Detalles Bibliográficos
Autores principales: Blencowe, Montgomery, Furterer, Allison, Wang, Qing, Gao, Fuying, Rosenberger, Madeline, Pei, Lina, Nomoto, Hiroshi, Mawla, Alex M., Huising, Mark O., Coppola, Giovanni, Yang, Xia, Butler, Peter C., Gurlo, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660728/
https://www.ncbi.nlm.nih.gov/pubmed/34554282
http://dx.doi.org/10.1007/s00125-021-05569-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660728/
https://www.ncbi.nlm.nih.gov/pubmed/34554282
http://dx.doi.org/10.1007/s00125-021-05569-2

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