Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with phosphorylated C-terminal tail (C tail) and transmembrane core (TM core) of GPCRs. However, the effects of the C tail- and TM core-mediated interactions on the conformati...

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Detalles Bibliográficos
Autores principales: Shiraishi, Yutaro, Kofuku, Yutaka, Ueda, Takumi, Pandey, Shubhi, Dwivedi-Agnihotri, Hemlata, Shukla, Arun K., Shimada, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660791/
https://www.ncbi.nlm.nih.gov/pubmed/34887409
http://dx.doi.org/10.1038/s41467-021-27482-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660791/
https://www.ncbi.nlm.nih.gov/pubmed/34887409
http://dx.doi.org/10.1038/s41467-021-27482-3

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