Peptide backbone modifications of amyloid β (1–40) impact fibrillation behavior and neuronal toxicity

Fibril formation of amyloid β (Aβ) peptides is one of the key molecular events connected to Alzheimer’s disease. The pathway of formation and mechanism of action of Aβ aggregates in biological systems is still object of very active research. To this end, systematic modifications of the Phe(19)–Leu(3...

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Detalles Bibliográficos
Autores principales: Schwarze, Benedikt, Korn, Alexander, Höfling, Corinna, Zeitschel, Ulrike, Krueger, Martin, Roßner, Steffen, Huster, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660793/
https://www.ncbi.nlm.nih.gov/pubmed/34887476
http://dx.doi.org/10.1038/s41598-021-03091-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660793/
https://www.ncbi.nlm.nih.gov/pubmed/34887476
http://dx.doi.org/10.1038/s41598-021-03091-4

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