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Peptide backbone modifications of amyloid β (1–40) impact fibrillation behavior and neuronal toxicity
Fibril formation of amyloid β (Aβ) peptides is one of the key molecular events connected to Alzheimer’s disease. The pathway of formation and mechanism of action of Aβ aggregates in biological systems is still object of very active research. To this end, systematic modifications of the Phe(19)–Leu(3...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660793/ https://www.ncbi.nlm.nih.gov/pubmed/34887476 http://dx.doi.org/10.1038/s41598-021-03091-4 |